Action Mechanism of curcumin actually still can not be explained, but apparently he can be bound to the enzyme aminopeptidase N (APN) and inhibits the activity of that enzyme.
APN is an enzyme present in membranes in the body tissue (known as a zinc-dependent metalloproteinase) and is responsible for angiogenesis and tumor growth. APN is a function to disassemble proteins on the surface of the body's tissue cells so that cancer cells can take over the position earlier and tissue cells to grow uncontrollably.
Provisional estimates, most likely an unsaturated bond (double bond), alpha and beta around the ketone group in curcumin to form covalent bonds with two amino acid nucleophile found on the active site and is able to inhibit APN (inhibit) activity is not - can return (irreversible) .
Today even the curcumin compound has entered the first phase of clinical trials for colon cancer withstand. Although the results of this study also inspire scientists to mimic or modify the structure of curcumin, but the excess compound curcumin from turmeric is a result of isolation of its natural and likely have little side effects on cancer patients.
Seeing the encouraging results of the research results, of course, we must not remain silent. Moreover, Indonesia has more variations and turmeric plant is one of the world's largest producer of turmeric (production + / - 12 tons / ha). Moreover, countries are now being intensively authorities science and technology - patented incessant many nuftah plasma originating from tropical countries like Indonesia. That is why we must take action to prevent and expand research on turmeric.
Sources: Health Secret of Tumeric (Kunyit), PT Elex Media Komputindo, Jakarta, 2011
APN is an enzyme present in membranes in the body tissue (known as a zinc-dependent metalloproteinase) and is responsible for angiogenesis and tumor growth. APN is a function to disassemble proteins on the surface of the body's tissue cells so that cancer cells can take over the position earlier and tissue cells to grow uncontrollably.
Provisional estimates, most likely an unsaturated bond (double bond), alpha and beta around the ketone group in curcumin to form covalent bonds with two amino acid nucleophile found on the active site and is able to inhibit APN (inhibit) activity is not - can return (irreversible) .
Today even the curcumin compound has entered the first phase of clinical trials for colon cancer withstand. Although the results of this study also inspire scientists to mimic or modify the structure of curcumin, but the excess compound curcumin from turmeric is a result of isolation of its natural and likely have little side effects on cancer patients.
Seeing the encouraging results of the research results, of course, we must not remain silent. Moreover, Indonesia has more variations and turmeric plant is one of the world's largest producer of turmeric (production + / - 12 tons / ha). Moreover, countries are now being intensively authorities science and technology - patented incessant many nuftah plasma originating from tropical countries like Indonesia. That is why we must take action to prevent and expand research on turmeric.
Sources: Health Secret of Tumeric (Kunyit), PT Elex Media Komputindo, Jakarta, 2011
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